5e Diseases

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Please leave the "(5e Disease)" identifier in the page title when creating your new disease!


See Also: 5e Diseases

Diseases Summary
Abber Flu Disease from the far realm which is passed through the befouled smog that comes from some abberant creatures lungs.
Abyssal Flames Your soul is being consumed
Acid Plague A infection of sores that contain acid
Alkali Fever If the air smells of metal, run.
An Arsonist's Curse When too many things burn, you do, too.
Arachnomania And you thought the Drider was the most monstrous spider out there?
Black Fly Filth Fever A disease spread by flies that causes the afflicted to slowly rot
Bleeding Swords don't just hurt you, silly! They make you BLEED!
Blowfat Syndrome Sickening disease that makes the afflicted bigger and fatter.
Botularia A mind-devouring infection characterized by moldy skin and bad taste. The infectious microform of the botularia.
Burning Thingy The tingling becomes a sudden pain between your legs...
Cheese Touch A horrifying affliction that turns one into an outcast.
Coddrow You now have a sudden and unnatural fear of sharp objects.
Coping Mechanism: Shutdown
Creeping Oak Slowly turns you into a tree.
Cyenzak's Brainworm (5e Spell)
Dance Fever A sickness that causes those afflicted to dance uncontrollably
Dead Frog Disease This disease is a deadly disease only found in wet tombs or deep in sewers
Death's Touch A cold seeps into your very bones and soul, enclosing an icy and deathly grip.
Dementia A horrible... sad disease and a.. uh... what else was there?
Dimensional Hiccups Dimensional instability manifesting in the form of hiccups.
Dracoshift Flu slowly and painfully turns one into a dragon. Hic Sunct Draconis.
Dread Esqueleto A dangerous disease that turns the infected into living bone.
Flame Venom Avoid the Dragon's tooth.
Fluvium An infection that causes fever and intense, lucid dreams. The infectious microform of the Fluvium.
Fog of the Mind A disease from a a mushroom spore, which causes your mind to fog.
Food Poisoning Have you ever asked your players "why did you eat that!?"
Form Reconstruction A disease which causes infected to melt and spread the disease to others.
Foulmonella A waterborne disease that stinking slime secretion and indifference. The infectious microform of the foulmonella.
Glitched The channeling of ones Ḡ̯͍̣̠̩̇̒̀̊ͅl͍̖̝ͨ͗̏i̜̦̗̇ͤ̎͌͌̎t̤̣ͨͨ̔̄̀̓̂c̭̖ͣ̇͒ͥͦh̐ͦ̏ into another host.
Hanahaki Disease Please...I beg you...love me back...
Impassioned Perception Sense the emotions of others around you
Infected Heart A disease which spreads infection through heartbeats.
Infection As wounds begin to fester, death becomes ever-present.
Innanonfeall Your internal organs swell, harming you when you move.
Ironrot A disease that slowly turns one into a ferrous material
Ligma A rare disease often affecting Fortnite streamers.
Miners Plague Miners' Plague is a disease that comes from mushrooms from the Underdark or similar locations. The Miners' Plague slowly infects the host until it forms sacks of pollen on it, then taking over it's mind making the target explode in a populated area killing the host and spreading the Plague.
Morph Fever A disease coming across from overuse of polymorph or from other magic sources.
Necrotic Disease A death dog is deadly indeed; one bite is all they need.
Night Terrors
Night Terrors; Persistent Variety
Nyctodiafora You ain’t seen nothin’ yet, son!
Otug's Disease A disease which afflicts you with mindless, uncontrollable rage.
Paranoia Paranoia is a mental condition which causes you to be irrationally suspicious towards others, often to the point of delusion.
Plague of Thorns, Variant Grow spikes, lose your hands
Pneumania A disease causing chills and fear. The infectious microform of the [Pneumania (5e Creature)|pneumania]].
Radiation Poisoning Sickness and afflictions caused by exposure to radiation.
Random Change
Rigor Vitalis A disease which causes bodily stiffness in the living.
Rotscale Flaky skin and an infection of the eyes can turn one into the stuff of nightmares.
Sailor's Strait You'll be dying, you'll be crying, early in the morning.
Salmon-ella You puke fish.
Scale Sickness/Dragon Lycanthropy This is much less awesome than it sounds, I promise.
Scrabies An insect-born disease characterized by an itching rash and hallucinatory infestation. The infectious microform of the scrabies.
Shadowflame Corruption Dark fires consume your soul with strange paranoia and eyes that seem to bear into your soul
Shivers Disease Shivers Disease is a common disease that makes the host sick with extreme vomiting,Heat sweats and Uncontrollable shivering. This disease spreads to other's through sweat.
Shrinking Sickness Spread by certain animals and plants to protect themselves.
Sigma Virus Tainted by the true viral form of Sigma, this behavioral disease turns Constructs violent and irrational, and in worse cases, into Sigma's puppets.
Silent Screams Nobody can hear your suffering if you can't even speak.
Sleeping Sickness
Snow Sickness The bane of travelers in the coldest regions.
Soot Skin A disease that slowly ravages your skin, gradually turning it to ash.
Spawn This will let you find your center.
Sphinx Pox Slowly, you become a sphinx
Spore Rot
Staphobia An aggressive infection characterized by necrosis and cannibalistic hunger. The infectious microform of the staphobia.
Stoneheart You feel your blood begin to thicken, and your body becomes hard to move...
Supraventricular Tachycardia (SVT) A disorder that makes one's heart beat faster than normal.
Terrortoma A cancerous infection that grants weaponized polyps at the cost of increased volatility. The infectious microform of the terrortoma.
The Blight From the outer gods, down onto the mortals. May you rot away.
The Plague A slow and painful death.
The Red Plague A blood disease contracted from contact with vampire's minions that causes potentially causes a slow transformation into being a vampire if not cured.
The Soups Have you ever had the displeasure of soup projecting out of both ends just because you got a little spooked?
The White Plague
Thief’s Burn
Transformational Plague You start transforming into other creatures you've touched.
Troll Thickening
Tunnel Vision “Wait, that isn’t 5e related?”
Useful Adventurer A disease causing creatures to become unnaturally (and painfully) useful.
Vile Polypore This disease of fungus debilitates its host and makes them a mindless automaton before ultimate death.
Viral Bullosa Skin becomes very delicate, causing its victim to be more easily injured.
Walter's Syndrome A strange disease that makes you speak in a constantly angry tone.
Weaver's Fever A flu-like disease. Annoying, but not lethal... unless you're a wizard.
Werepyre Curse This is what happens when a victim gets bit by a werewolf and vampire, both.
Wonky Body The afflicted’s body changes randomly, and becomes extremely awkward and possibly debilitating.
Zombie Virus Get bit by a zombie, become a zombie

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Please leave the "(5e Curse)" identifier in the page title when creating your new curse!


For when you want something a little more supernatural, that your paladins can be afflicted with

Curses Summary
A Day in Seven Lives Turns you into a completely different person each day for seven days.
Altren's Mark You bear the cursed and blessed mark of Altren, that weakens your body.
Asmodeus Junior's Luck cursed to have the luck of the tefling Asmodeus junior
Bad Juju A curse that makes the "infected" clumsy and have bad luck.
Baneweaver Curse Something made mother nature mad. You should probably find out what.
Beggar's Curse of the Sea A certain wish that changed everything due to selfishness
Broken Halo A curse placed on a high priest or paladin for acting against their god's will.
Crimson Curse A vampiric curse spread from the Crimson Court
Curse of Booming Words No matter how quietly you try to speak, your words boom thunderously.
Curse of Ill Entry A spike of pain shoots through you each time you pass through a doorway.
Curse of Immortality Your spirit remains forcefully bound to your body, confining it to never experience its place in the outer planes.
Curse of Incompetence Reduce your proficiency score!
Curse of the River Goddess A dehydrating curse created by a spiteful river goddess.
Curse of the Ultima This curse created the first werewolf that is not a lycanthrope. Because of this curse, you, and only your type can turn people with human blood running in their veins into your kind
Devil's Cuse You have tried to swindle a devil and failed to fulfill your end of the bargain.
Fiend Fever *not actually a fever
Greed’s Death, Variant Cough up gold! Could be fatal...
Jusenkyo Accursed You have fallen into the cursed springs of the legendary training ground Jusenkyo, and now you transform whenever you come into contact with cold water.
Lost or Found you have zero sense of direction and get lost at every minute, although sometimes you simply know the location of everything.
Nature's Rage May you engage in brutal combat
Project G.O.R.O. Go, Out Run, Oppress
Ragnarok Mark You are now virtual property of the gods upon your end
Sacrosanct Those who stand by the sword shall die by it.
Sinister Sleepwalking
Teleglow The matter in your body doesn't want to stay there, and the things that shouldn't be there suddenly are
The Adventuring Curse A curse designed to make Shawn Spellblade unstoppable. Not that he cared to be.
The Curse of Many Babies Disrespect kids, get the opposite back.
The Stiffening Slowly your muscles and joints harden
Trumpet's Bane Trumpets sound nice normally, right?
VIRUS The power to make a deity despair by sealing their power... That is VIRUS.
Witch's Curse Fly, my pretties! Fly!
Wooden Fingers Yes, your fingers turn into small, curly branches of a tree.

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