Prion of Madness (4e Disease)

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Prion of Madness
Level 25 Disease
This rogue protein from the Plane of Limbo has a chance of infecting a host who has consumed flesh from a being from Limbo. The prion buries itself into the victim's brain and drives them to madness.

Stage 0: The target recovers from the disease.

Stage 1: Your body's peripheral limbs begin to malfunction. Every hour, you immediately drop prone on the floor and drop everything you are holding.
Stage 2: The body returns to some normalcy and the prone spasms stop. But a murderous urge comes on. At the beginning of each of your turns in combat, you must roll a d6. On a roll of 1 or 2, you target the nearest ally with your attack instead of an enemy.
Stage 3: (Final Stage) In addition to the effects of Stage 2, you become utterly incoherent and your brain begins to rot. You are unable to make Bluff or Diplomacy checks. Also, at the beginning of every encounter, you take 25 necrotic damage. You cannot regain hit points lost this way until you are out of stage 3.

Check: At the end of each extended rest, the target makes an Endurance check. They cannot make this check if they reach stage 3.
18 or Lower: The stage of the disease increases by 1.
19 - 29: No change.
30 or Higher: The stage of the disease decreases by 1.

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